Thursday, March 10, 2011
Receptor tyrosine kinases (receptors for various growth factors)
Juxtamembrane autoinhibition in receptor tyrosine kinases
The discovery of receptor tyrosine kinases: targets for cancer therapy
Tyrosine-Kinase Receptor occurs as follows:
Figure 1: Receptor tyrosine kinase (RTK) signaling: Upon ligand binding and
Tyrosine-Kinase Receptors often have a structure similar to the diagram
Inhibiting receptor tyrosine kinase activity
Receptor Tyrosine Kinases, TCR and TNF pathways
Receptor Tyrosine Kinase Overexpressed in Breast Cancer. (Enlarge Slide)
FGF and ILGFs act through receptor tyrosine kinases to activate PI3K
and distribute a signal, or inhibit a signal by limiting the lifetime of
Mechanism of action of tyrosine kinase. 1. Receptor expression at membrane
Juxtamembrane autoinhibition in receptor tyrosine kinases
monoclonal antibodies for targeting receptor tyrosine kinases in cancer
Receptor tyrosine kinase families (74). The following structural features
Insulin Receptor Tyrosine kinase and a crystal structure of IRTK has
Figure 34.27 · The three classes of receptor tyrosine kinases.
The atypical receptor tyrosine kinase, Ryk, acts as a Wnt co-receptor.
Schematic representation of the different families of the receptor tyrosine
VEGF receptor tyrosine kinase inhibitors with antitumor activity.
